Endocrine IntelligenceA technical deep-dive into the physiological impact of synthetic androgens, hormonal feedback loops, and metabolic risk management.
Database Sync: OptimizedSecurity Protocol: WADA Standard
Updated: 2025.12.29
01. Pharmacology & Mechanism
Anabolic-Androgenic Steroids (AAS) function as agonists for the **Androgen Receptor (AR)**. Once bound, the AR-complex translocates to the cell nucleus, altering gene expression to increase protein synthesis and nitrogen retention.
The Feedback LoopExogenous supply triggers the Hypothalamic-Pituitary-Testicular Axis (HPTA) to cease natural production of LH and FSH, leading to testicular atrophy.
02. The Compound MatrixVERIFIED DATA // 2025
Molecular Base
Class
Anabolic Ratio
Primary Risk
Testosterone
Base Ester
100:100
Aromatization (E2)
Trenbolone
19-Nor
500:500
Neurotoxicity/Prolactin
Methandrostenolone
Oral C17-aa
210:60
Hepatotoxicity (Liver)
Oxandrolone
DHT Deriv.
322:24
Lipid Strain (HDL/LDL)
🫀
Cardiovascular StrainInduced **Left Ventricular Hypertrophy (LVH)** and arterial plaque acceleration. Chronic use leads to decreased cardiac output and thickening of heart walls.
🧠
Neuro-Endocrine shiftAlteration of the **Dopaminergic System** and GABA receptors. Results in heightened aggression (Amygdala over-activity) and acute mood volatility.
🧪
Metabolic ToxicityC17-alpha alkylated orals prevent first-pass metabolism, causing **Cholestasis** and elevated ALT/AST enzymes, potentially leading to adenomas.
Tactical Harm Reduction
01
Diagnostic BloodworkBi-monthly screening of Lipid profiles, CBC (Hematocrit), and Kidney function (Cystatin-C).
02
HPTA Restoration (PCT)Use of SERMs (Nolvadex/Clomid) to restart the Pituitary signal for natural Testosterone production.
03
Ancillary ManagementStrict control of Serum Estradiol and Prolactin via Aromatase Inhibitors or Dopamine Agonists.
04
Organ SupportSupplementation with TUDCA, NAC, and Telmisartan for liver and blood pressure protection.
⚠️
Legal & Medical WarningThis document is for information only. Possession of AAS without a prescription is a felony in many jurisdictions. Supraphysiological androgen use can cause irreversible endocrine shutdown. Always consult a licensed Endocrinologist.